中国现代医生Issue(24)：37-39,3.
坦洛新缓释胶囊联合全雄激素阻断治疗晚期前列腺癌伴膀胱出口梗阻的疗效
Efficacy of tamsulosin sustained release capsules combined with maximal androgen blockade in treatment of advanced prostate cancer concurrent with bladder outlet obstruction
摘要
Abstract
Objective To investigate the efficacy of tamsulosin sustained release capsules combined with maximal an-drogen blockade in the treatment of advanced prostate cancer concurrent with bladder outlet obstruction. Methods Six-ty-eight patients with advanced prostate cancer concurrent with bladder outlet obstruction were randomly divided into the observation group and the control group. Both groups received maximal androgen blockade treatment, on the basis of which the observation group received oral tamsulosin sustained release capsules 0.2 mg and once a day. The treat-ment course was 4 months for two groups. Results After 4 months of treatment, QOL and Qmax of two groups elevated significantly than before treatment, and IPSS score, RU and TPSA reduced significantly than before treatment(P<0.05 or P<0.01). And the improvement degrees of IPSS, QOL, Qmax and RU of the observation group were significantly better than those of the control group (P<0.05). No obvious drug adverse reactions occurred in the control group and 1 case of mild positional dizziness occurred in the observation group. Conclusion In the treatment of patients with advanced prostate cancer, tamsulosin sustained release capsules combined with maximal androgen blockade can rapidly improve the patients' LUTS symptoms, improve the patients' quality of life, and is safe and economical.关键词
前列腺癌/膀胱出口梗阻/坦洛新缓释胶囊/全雄激素阻断Key words
Prostate cancer/Bladder outlet obstruction/Tamsulosin sustained release capsules/Maximal androgen blockade分类
医药卫生引用本文复制引用
金刚,韩子华,汪官富..坦洛新缓释胶囊联合全雄激素阻断治疗晚期前列腺癌伴膀胱出口梗阻的疗效[J].中国现代医生,2014,(24):37-39,3.基金项目
浙江省医学会临床科研基金项目 （）
