中国现代医生Issue(25)：7-9,12,4.
母胎ABO血型不合孕妇血型IgG抗体效价与围产儿溶血病相关性分析
Correlation analysis between blood type IgG antibody valence and hemolytic disease of newborn (HDN) of pregnant women with maternal-fetal ABO blood type incompatibility
摘要
Abstract
Objective To investigate the correlation between the blood type IgG antibody valence and the hemolytic disease of newborn (HDN) of the pregnancy women with maternal-fetal ABO blood type incompatibility. Methods 2137 pregnant women with blood type incompatibility who delivered in the obstetrical department of our hospital from September 2011 to February 2014 and their neonates were selected as the study subjects. The last serum IgG antibody valence equal to or greater than 64 served as the clinical standard. After birth, the neonates' HDN related indicators were examined. The correlation between pregnant women's blood type IgG antibody valence and HDN and the risk factors were analyzed. Results Of the 2137 pregnant women with ABO blood type incompatibility, 458 perinatal infants had hemolysis. As the pregnant women's IgG antibody valence increased, the incidence of HDN rose significantly;Pearson correlation analysis showed that the correlation coefficient was r=0.82. Univariate analysis found that increase of number of pregnancies, increase of age, poor childbearing history and other factors were independent risk factors of HDN. Conclusion Before birth, blood type examination of couples and fetuses should be enhanced, IgG antibody de-tection of pregnant women with maternal-fetal ABO blood type incompatibility should be conducted, the pregnant women with advanced age, multiple pregnancies and adverse pregnancy history should be monitored closely, and proper intervention should be implemented in order to avoid the occurrence of HDN.关键词
孕妇/血型抗体/围产儿/溶血病Key words
Pregnant women/Blood type antibody/Perinatal/Hemolytic disease分类
医药卫生引用本文复制引用
杨玮丽,张云怡..母胎ABO血型不合孕妇血型IgG抗体效价与围产儿溶血病相关性分析[J].中国现代医生,2014,(25):7-9,12,4.基金项目
浙江省医药卫生科技计划项目 （）
