中国现代医生Issue(26)：1-4,4.
桑叶黄酮对2型糖尿病并发单纯性脂肪肝大鼠肝组织PPARγ的影响
Effect of mulberry flavone on liver PPARγ in type 2 diabetic rats with simple fatty liver
摘要
Abstract
Objective To establish type 2 diabetic rats with simple fatty liver model,observed the efficacy effect of mulberry flavone on rat liver PPARγ,and to explore the possible molecular mechanism of fatty liver and how mulberry flavone improves insulin resistance. Methods Rats were fed with high-fatty diet,then small doses of streptozotion (STZ) were injected intraperitoneally to type 2 diabetic rats with simple fatty liver model. Then part of the rats were fed with mulberry flavone and rosiglitazone. The fasting blood glucoses, fasting insulins and PPARγ were measured.Then ob-served the variety of PPARγ in rat liver. Results ①Compared with normal group (NOR),insulin sensitivity indexes were significantly lower in model group (MOD),but it was increased in mulberry flavone (MLF) and rosiglitazone group (RGZ),and there was no significant difference between MLF and RGZ.②Compared with NOR group, the PPARγof rat liver were significantly reduced in MOD,and increased in MLF and RGZ, but also it had no significant difference be-tween MLF and RGZ. Conclusion Mulberry flavone can improve insulin sensitivity in type 2 diabetic rats with simple fatty liver, also can improve insulin resistance, and this effect is possible related about the increased PPARγof rat liver.关键词
桑叶黄酮/2型糖尿病/脂肪肝/PPARγ/胰岛素抵抗Key words
Mulberry flavone/Type 2 diabetes/Fatty liver/PPARγ/Insulin resistance分类
医药卫生引用本文复制引用
薛城敬,苏言辉,王亚洲,李慧,马婷婷,陈秋..桑叶黄酮对2型糖尿病并发单纯性脂肪肝大鼠肝组织PPARγ的影响[J].中国现代医生,2014,(26):1-4,4.基金项目
教育部新世纪优秀人才支持计划（NCET08-0903）；四川省中医药管理局重点课题 （）
