中国现代医生Issue(29)：4-6,3.
老年患者医院获得性肺炎血清可溶性髓系细胞触发受体-1、核转录因子-κB和白细胞介素-8水平变化的研究
Changes of serum sTREM-1, NF-κB and IL-8 levels in senile patients with hospital-acquired pneumonia
摘要
Abstract
Objective To observe the changes of soluble triggering receptor expressed on myeloid cell-1 (sTREM-1)and inflammatory mediators in serum of senile patients with hospital-acquired pneumonia and explored the state of local inflammatory response in HAP. Methods Twenty senile patients with HAP and twenty healthy controls were in-cluded. Serum sTREM-1, nuclear factor-κB (NF-κB) and interleukin-8 (IL-8) were detected on day 1, 5, 10. Com-bined with CPIS score to analyze the correlation of these indicators and the severity and prognosis of pneumonia. Re-sults The concentrations of sTREM-1, NF-κB and IL-8 in serum were significantly higher than those in controls. There was a significant positive correlation between the sTREM-1, NF-κB and IL-8 and CPIS score. Conclusion sTREM-1, NF-κB and IL-8 is a good marker in diagnosing pneumonia. The levels of sTREM-1, NF-κB and IL-8 have a positive correlation with severity of HAP.关键词
医院获得性肺炎/可溶性髓系细胞触发受体-1/核转录因子-资B/白细胞介素-8Key words
Hospital-acquired pneumonia/Soluble triggering receptor expressed on myeloid cell-1/Nuclear factor-κB/Interleukin-8分类
医药卫生引用本文复制引用
王彦蕊,张志岷,陈瑀,滕忠强,傅凌玲,林娟..老年患者医院获得性肺炎血清可溶性髓系细胞触发受体-1、核转录因子-κB和白细胞介素-8水平变化的研究[J].中国现代医生,2014,(29):4-6,3.基金项目
福建省卫生厅青年科研基金 （）
