摘要
Abstract
Objective To observe the influence of low-dose dexmedetomidine combined with sufentanil PCIA on post-operative delirium in elderly patients undergoing hip fracture surgery. Methods Sixty elderly patients aged 65~80, ASAⅠorII, undergoing elective hip fracture surgery by combined spinal-epidural anesthesia were randomly allocated to receive dexmedetomidine combined with sufentanil PCIA group (group D, n=30) and sufentanil PCIA group (group S, n=30). The scores of visual analogue scales (VAS) was recorded at 6、12、24 and 48 h after operation, and cognitive function was assessed 1 d preoperatively and on the postoperative 2, 4 and 6 d with MMSE and CAM after PCIA. Re-sults The VAS scores in each time point of two groups after operation were both ≤4, there was no significantly differ-ence in the pain score between two groups, in group D, times of press analgesia device was less than that in group S (P<0.01); The MMSE score in D group was higher than that in S group on the postoperative 2, 4 and 6 d (P<0.05) and the incidence of postoperative delirium in group D (n=2) was lower than group S(n=8) (6.7% vs 26.7%)(P<0.05). The patients in the two groups had no respiratory suppression. Conclusion Low-dose dexmedetomidine combined with sufentanil PCIA in elderly patients undergoing hip fracture surgery has satisfactory analgesic effect, and can decrease the incidence of postoperative delirium.关键词
右美托咪定/老年患者/自控镇痛/术后谵妄Key words
Dexmedetomidine/Elderly/PCIA/Postoperative delirium分类
医药卫生
