摘要
Abstract
Objective To evaluate efficacy and side effect profile of pituitrin or oxytocin in the laparoscopic myomecto-my,and further to elucidate the clinical value of the two drugs. Methods Searched in the electronic database to get randomized controlled trials about the effect of pituitrin or oxytocin for laparoscopic myomectomy. Data which accord with the standard clinical studies were analyzed by Meta analysis. Results A total of 22 articles were included in the study. The results of meta analysis showed that pituitrin was more effective than oxytocin in the control of the operation time(MD=-28,95%CI-21~-35), reduced the amount of bleeding(MD=-51,95%CI-32~-70), reduced the postoper-ative hemoglobin decrease(MD=-3.8,95%CI-2.3~-5.2). But the side effects of high blood pressure in pituitrin group were more serious than that in the oxytocin group(OR=2.25,95%CI 1.90~2.60). Conclusion Pituitrin in the application of laparoscopic myomectomy could shorten the operation time , reduce intraoperative blood loss , lower postoperative hemoglobin decreased, but the probability of occurrence of high blood pressure in patients with significantly higher than that of oxytocin, strictly grasp the operation indication and contraindication is to improve the surgical success rate and reduce complications.关键词
垂体后叶素/缩宫素/子宫肌瘤/Meta分析Key words
Pituitrin/Oxytocin/Uterine myoma/Meta-analysis分类
医药卫生
