中国现代医生Issue(3)：77-79,83,4.
胰腺癌术后预防性肝动脉灌注化疗的临床研究
Clinical research of prophylactic hepatic artery infusion chemotherapy af-ter curative resection in patients with pancreatic cancer
摘要
Abstract
Objective To explore the effect of prophylactic hepatic artery infusion chemotherapy (HAIC) on survival after curative resection in patients with primary pancreatic cancer. Methods A total of 106 patients with pancreatic cancer after pancreatectomy received 2 cycles of HAIC plus 4 cycles of systemic chemotherapy (HAIC) or 6 cycles of sys-temic chemotherapy alone (Control). Both the HAIC and systemic chemotherapy regimen consisted of 5-fluorouracil 1000 mg/m2 on day 1 and Gemcitabine 800 mg/m2 on day 1 and 8. The treatment was started on an average of 3 weeks after surgery and repeated every 4 weeks. The disease-free survival , overall survival and liver metastases-free survival were compared. Results Significant differences were found in 3-year overall survival (HAIC, 23.08 %; Control, 14.81%;P=0.0473) and liver metastases-free survival (HAIC, 80.77%;Control, 55.56%;P=0.0014). There was no significant difference in adverse effects between two groups. Conclusion HAIC effectively and safely prevented liver metastases and improved the prognosis of patients with pancreatic cancer after pancreatectomy.关键词
胰腺癌/肝动脉灌注化疗/肝内复发/转移Key words
Pancreatic cancer/Hepatic artery infusion chemotherapy/Intrahepatic recurrence/Metastases分类
医药卫生引用本文复制引用
姚利琴,唐成武,冯文明,鲍鹰,郑银元..胰腺癌术后预防性肝动脉灌注化疗的临床研究[J].中国现代医生,2015,(3):77-79,83,4.基金项目
浙江省省部共建资助项目 （）
