摘要
Abstract
Objective To investigate the effect of TNF-related apoptosis inducing ligand (TRAIL) in inducing apopto-sis in non-small cell lung cancer, and to explore the feasibility of TRAIL in treatment of lung cancer. Methods The single group: the cells in the two group with solutions of different concentrations of TRAIL A549 and the feasibility of TRAIL treatment between the NSCLC group and the Jurkat leukemia cell group was compared. The combination group: same concentrations of TRAIL combined with different chemotherapy treatment A549 and the corresponding chemotherapy drugs were compared, apoptosis was detected by MTT assay before and after treatment of A549 cells the incidence of parallel statistical comparison. Results TRAIL was able to make part of the non-small cell lung cancer apoptosis in vitro, TRAIL apoptosis rate and concentration had a positive correlation to some extent;TRAIL solution after combination chemotherapy drugs kill tumor cells was significantly stronger ability to eliminate drugs in the chemothera-py alone, the difference was statistically significant (P<0.05). Conclusion TRAIL can induce lung cancer cells in vitro, small portion of non-small cell apoptosis of apoptosis within a certain range of concentrations are positively related with TRAIL, TRAIL combined chemotherapy drugs have synergistic apoptosis of tumor cells.关键词
非小细胞肺癌/肿瘤坏死因子相关凋亡诱导配体/凋亡Key words
Non-small cell lung cancer/Tumor necrosis factor-related apoptosis inducing ligand/Apoptosis分类
医药卫生
