肿瘤坏死因子相关凋亡诱导配体对非小细胞肺癌细胞凋亡诱导的实验研究OA
Induction of apoptosis with TRAIL in non-small lung cancer
目的:研究肿瘤坏死因子相关凋亡诱导配体(TRAIL)对非小细胞肺癌肿瘤细胞体外诱导凋亡作用,探讨TRAIL治疗肺癌的可行性。方法(1)单用组:单用不同浓度的TRAIL溶液处理A549并与白血病Jurkat细胞对照;(2)联合组:相同浓度的TRAIL联合不同化疗药物处理A549并与对应的单纯化疗药物对照,用MTT法及流式细胞仪检测处理前后A549细胞的凋亡发生率并比较。结果 TRAIL溶液能使部分体外非小细胞肺癌发生凋亡,TRAIL溶液浓度与细胞凋…查看全部>>
Objective To investigate the effect of TNF-related apoptosis inducing ligand (TRAIL) in inducing apopto-sis in non-small cell lung cancer, and to explore the feasibility of TRAIL in treatment of lung cancer. Methods The single group: the cells in the two group with solutions of different concentrations of TRAIL A549 and the feasibility of TRAIL treatment between the NSCLC group and the Jurkat leukemia cell group was compared. The combination group: same conc…查看全部>>
王建新
南阳医学高等专科学校第一附属医院肿瘤内科2病区,河南南阳 473058
医药卫生
非小细胞肺癌肿瘤坏死因子相关凋亡诱导配体凋亡
Non-small cell lung cancerTumor necrosis factor-related apoptosis inducing ligandApoptosis
《中国现代医生》 2015 (14)
1-3,3
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