中国现代医生Issue(14)：47-50,4.
胎儿孕周对中期唐氏筛查效率的影响
Effects of fetus gestational weeks on efficiency of Down's Screening dur-ing the second trimester
摘要
Abstract
Objective To observe and analyze the effects of fetus gestational weeks on efficiency of Down's screening during the second trimester, and to provide certain reference data clinically. Methods A total of 36515 puerpera who received prenatal screening during the second trimester were selected. They were assigned to 5 groups according to their gestational weeks, which were group of 15 gestational weeks(15 to 16+6), group of 16 gestational weeks (16 to 16+6), group of 17 gestational weeks(17 to 17+6), group of 18 gestational weeks (18 to 18+6) and group of 19 ges-tational weeks (19 to 20 weeks). Detection rate and false screening positive rate of infants with Down's syndrome were compared between different gestation weeks. Results Two cases of missed diagnosis were seen in puerpera in the group of 15 gestation weeks. Detection rate of Down's screening in the group of 16 weeks to 18 weeks was 100%. No diagnosed infants with Down's syndrome were seen in the group of 19 gestational weeks. The false positive rate therefore was 7.85%. The screening results were different during different gestational weeks. Detection rate during 16 to 18 gestation weeks was 100%, and false positive rate of screening was 4.36%. In the negative groups of screened puerpera, AFP level increased with the increase of gestational weeks, and HCG level decreased with the increase of gestational weeks. In the positive groups of screened puerpera,their AFP levels were all lower than those in the nega-tive groups,and there HCG levels were higher than those in the negative groups. Conclusion Efficiency of screening is high when Down's screening during the second trimester of pregnancy is carried out during 16 to 18 gestational weeks.关键词
胎儿孕周/中期唐氏筛查/效率Key words
Fetus gestational weeks/Down's screening during the second trimester/Efficiency分类
医药卫生引用本文复制引用
柯汝淑,陈雪华,赵小红,陈雅..胎儿孕周对中期唐氏筛查效率的影响[J].中国现代医生,2015,(14):47-50,4.基金项目
浙江省医药卫生科技计划项目（2009A198）；浙江省温州市科技局项目（Y20130123）；浙江省瑞安市科技计划资助项目 （）
