中国现代医生Issue(15)：1-3,10,4.
银杏叶提取物对慢性低O2高CO2大鼠空间学习记忆的影响
The effect of gingkgo biloba extra on spatial learning-memory in rats with chronic hypoxic hypercapnia
摘要
Abstract
Objective To observe changes of spatial learning-memory in rats with chronic hypoxic hypercapnia and the effect of gingkgo biloba extra. Methods After established the rat model of chronic hypoxic hypercapnia,seventy-two rats were randomly divided into four groups normal control (NC),hypoxic-hypercapnia 4-week (4HH),hypoxic-hy-percapnia 4-week+gingkgo biloba extra (EGb)high dose(100 mg/kg)group[4HH+EGb(H)] and hypoxic-hypercapnia 4-week+EGb low dose (50 mg/kg) group[4HH+EGb(L)]. Praxiology in rats was asessed by the Morris water maze and step down test. Results The spatial learning-memory in rats exposed to chronic hypoxic-hypercapnia 4-week(4HH group)were displayed significant impairment in their performance,the longer mean escape latencies and swim path dis tances,the more error times. 4HH+EGb(H) and 4HH+EGb(L)groups shortened the reaction time of leaning, pro longed the latent time of memory, reduced times of mistakes. Conclusions EGb can enhance the capacity of learning-memory in the rats exposed chronic hypoxic hypercapnia.关键词
慢性低O2高CO2/银杏叶提取物/行为学/Morris水迷宫Key words
Chronic hypoxic hypercapnia/Gingkgo biloba extra/Praxiology/Morris water maze分类
医药卫生引用本文复制引用
陈松芳,邵胜敏,胡蓓蕾,何志勇,王小同,龚永生,周红宇..银杏叶提取物对慢性低O2高CO2大鼠空间学习记忆的影响[J].中国现代医生,2015,(15):1-3,10,4.基金项目
浙江省中医药青年课题 （）
