中国现代医生Issue(15)：67-69,3.
替莫唑胺联合放疗同步治疗胶质母细胞瘤的疗效观察
Observation of the curative effect of temozolomide combined with radio-therapy in the treatment of malignant gliomas
王重韧 1徐欣 1尤宇 1韩磊 1赵四军 1赵明1
作者信息
- 1. 郑州大学附属肿瘤医院神经外科，河南郑州 450008
- 折叠
摘要
Abstract
Objective To observe the clinical effect of temozolomide combined with radiotherapy in the treatment of malignant gliomas. Methods A total of 64 patients with pathologically confirmed glioblastoma received radiotherapy combined with chemotherapy in our hospital from January 2008 to January 2014, radiotherapy synchronized with TMZ chemotherapy were used in 39 patients (synchronized group) and radiotherapy sequential with TMZ chemotherapy in 25 patients (sequential group).1 year and 3 year survival rates, response rate and drug safety were compared between the two groups. Results The patients were followed up for 6 months to 3 years, the synchronous group of patients 1 years and 3 years survival rates (74.4%, 38.5%) were higher than the sequential group(64.0%, 28.0%) (P<0.05), objective re-sponse rate of two groups were 64.1%and 44.0%, the difference was statistically significant(P<0.05), gastrointestinal re-action rates of two groups were 23.1% and 20.0%, the difference was not statistically significant (P>0.05). Adverse re-actions were statistically significant (P<0.05). Conclusion The effect of radiotherapy synchronized combined with TMZ chemotherapy is better than radiotherapy sequential with TMZ chemotherapy for glioblastoma, it is still the first choice for the treatment of glioblastoma although the clinical manifestations of toxicity increased than the sequential group.关键词
胶质母细胞瘤/替莫唑胺/联合放疗/同步治疗/生活质量Key words
Malignant glioma/Temozolomide/Combined with radiotherapy/Synchronization treatment/Quality of life分类
医药卫生引用本文复制引用
王重韧,徐欣,尤宇,韩磊,赵四军,赵明..替莫唑胺联合放疗同步治疗胶质母细胞瘤的疗效观察[J].中国现代医生,2015,(15):67-69,3.
