中国现代医生Issue(16)：4-7,4.
脓毒症急性肾损伤的早期诊断及生大黄的疗效研究
Early diagnosis and therapeutic effect of rhubarb for septic acute kidney injury
摘要
Abstract
Objective To study early diagnostic index of septic acute kidney injury(AKI) and protective effect of rhubarb on septic AKI. Methods Sixty rats were randomly divided into the following 3 groups:model group (A), treatment group (B) and control group (C). Each group contains 20 rats. Rats from group A were received a intraperitoneal injection of lipopolysaccharide (LPS) at a dose of 5 mg/kg to induce AKI. Rats from group B were given rhubarb powder solution by oral administration immediately after LPS injection. Rats from group C were treated with the same volume of normal saline (NS) by intraperitoneal injection. Both serum level of creatinine (Scr) and urinary levels of Netrin-1 and KIM-1 of rats in 3 groups were detected in the different time points of treatment (0 h, 1 h, 6 h and 24 h). Results The levels of KIM-1 and CR in rats treated with LPS were obviously increased at the time point of 6 h (P<0.05). The urinary lev-el of Netrin-1 began to increase at the time point of 1 h and reached the highest level at the time point of 6 h, then gradually decreased at the time point of 24 h after the injection of LPS. In group B, the levels of Scr, Netrin-1 and KIM-1 were significantly lower as compared with group A (P<0.05). Conclusion The urinary level of Netrin-1 might has early diagnostic value in septic acute kidney injury. Rhubarb could protect the kidney of AKI model rats by de-creasing the serum level of Scr, urinary levels of Netrin-1 and KIM-1.关键词
急性肾损伤/脓毒症/生大黄/Netrin-1Key words
Acute kidney injury/Sepsis/Rhubarb/Netrin-1分类
医药卫生引用本文复制引用
韩芳,吴爱萍,孙仁华..脓毒症急性肾损伤的早期诊断及生大黄的疗效研究[J].中国现代医生,2015,(16):4-7,4.基金项目
浙江省重点科技创新团队 （）
