摘要
Abstract
Objective To investigate the clinical efficacy of valsartan combined with alprostadil in treating diabetic nephropathy. Methods A total of 64 cases of diabetic nephropathy patients diagnosed from June 2012 to June 2014 ac-cording to the ratio of 1:1 in all patients were randomly assigned to study group and control group, 32 cases in each group, two groups were treated with hypoglycemic, antihypertensive therapy, meanwhile with diet and proper exercise, control group was treated with valsartan tablets 80 mg, 1 time, oral daily, for 4 weeks, the study group combined with alprostadil in 100 mL NaCl, solution 100 μg, intravenous drip, 1 time a day, for 4 weeks. The total efficiency of the two groups before and after treatment, and BUN, UAER, SCr indexes change of two groups were compared. Results The treatment efficacy of the two groups were compared after 4 weeks, the total efficacy rate of the study group was 93.75%, compared with the control group's 71.88%, the difference was statistically significant (P<0.05). BUN, UAER, SCr levels of two groups were significantly lower after treatment, and the BUN, UAER, SCr levels of study group after treatment decreased more significantly than the control group, the difference was statistically significant (t=2.754, 3.632, 3.247, P<0.05). Conclusion Valsartancombined combined with alprostadil can improve the clinical curative effect of diabetic nephropathy, improve renal function, with good safety, and is worthy of promotion and application.关键词
糖尿病肾病/缬沙坦/前列地尔Key words
Diabetic nephropathy/Valsartan/Alprostadil分类
医药卫生
