中外医学研究Issue(5)：17-19,20,4.DOI:10.14033/j.cnki.cfmr.2015.05.08
CTLA-4基因外显子49位点多态性与重症肌无力的相关性研究
A Correlation Study between the CTLA-4 at Exon 49 Single Nucleotide Polymorphisms and Myasthenia Gravis
彭忠伟 1刘肇绩 1郑维红1
作者信息
- 1. 厦门大学附属中山医院 福建 厦门 361004
- 折叠
摘要
Abstract
Objective:To investigate the relevance of CTLA-4 exon region 49A/G single nucleotide polymorphisms and myasthenia gravis patients in Fujian province.Method:The CTLA-4 gene exon 1 region+49A/G polymorphism of myasthenia gravis patients in Fujian area were detected by PCR amplification and restriction fragment length polymorphism method.Result:There were no significant differences between the MG group and the control group in 49A/G locus allele and genotype,and there was no significant connection between MG and CTLA-4 exon 49 single nucleotide polymorphisms in myasthenia gravis patients(P>0.05).The frequency of GG genotype in male patients with MG was significantly higher than female patients(χ²GG=4.41, P=0.04).Conclusion:MG may be not correlated with the haplotype and genotype of CTLA-4 at exon 49 in Fujian area.关键词
重症肌无力/细胞毒性T淋巴细胞相关抗原-4/基因多态性Key words
Myasthenia gravis/Cytotoxic T lymphocyte associated antigen-4/Gene polymorphisms分类
医药卫生引用本文复制引用
彭忠伟,刘肇绩,郑维红..CTLA-4基因外显子49位点多态性与重症肌无力的相关性研究[J].中外医学研究,2015,(5):17-19,20,4.
