中外医学研究Issue(11)：3-5,3.DOI:10.14033/j.cnki.cfmr.2015.11.002
凝血酶敏感蛋白-1及其受体CD36在支气管肺发育不良患儿中的表达及临床意义
Expression and Clinical Significance of Thrombospodin-1 and Its Receptor CD36 in Neonatus with Bronchopulmonary Dysplasia
摘要
Abstract
Objective:To investigate the expression and clinical significance of thrombospodin-1 (TSP-1) and its receptor CD36 in bronchopulmonary dysplasia (BPD) children serum and bronchoalveolar lavage fluid.Method:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children(n=45) and non-BPD neonatus(n=32) were detected by ELISA.Correlations of TSP-1 and CD36 levels and the comparisons between groups were analyzed respectively.Result:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children were significantly higher than those of non-BPD neonates respectively(P<0.05).There was a positive correlation relationship between the expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid(P<0.05).Conclusion:TSP-1 and CD36 may play a role in the pathogenesis of neonatus BPD and act cooperatively through an unexplored mechanism,the specific mechanism needs further study.关键词
凝血酶敏感蛋白-1/CD36/支气管肺发育不良/ELISAKey words
Thrombospodin-1/CD36/Bronchopulmonary dysplasia/ELISA分类
医药卫生引用本文复制引用
杨敏,李林瑞,孟燕妮,陈艳萍..凝血酶敏感蛋白-1及其受体CD36在支气管肺发育不良患儿中的表达及临床意义[J].中外医学研究,2015,(11):3-5,3.基金项目
湖南省科技计划项目(项目编号2012SK3256) （项目编号2012SK3256）
