中国现代中药Issue(6)：556-559,4.DOI:10.13313/j.issn.1673-4890.2015.6.009
快律宁胶囊对外源性自由基所致心律失常的影响
Effect of Fast Law Capsule on Arrhythmias Induced by Exogenous Free Radical
摘要
Abstract
Objective:To study the effect of the Fast-law Capsules(KLN)on arrhythmias induced by exogenous free radical,and compare the protective effect,between KLN and verapamil.Methods:SPF SD rats were divided into control group,verapamil group and KLN capsules high,medium and low-dose groups,the method of ferrous sulfate /ascorbic acid Langendoff perfusion of isolated rat heart was applied,exogenous free radicals induced arrhythmias in rats was copied.Results:Compared with the control group,KLN capsule showed a dose-dependent reduction in the number of occurrences of exogenous free radicals induced VEB and VT(P <0.01).VF did not occured in KLN capsule three dose groups and verapamil group, while the control group induced VF,but there was no significant difference(P >0.05)by the statistics.Compared with the control group,the emergence of high-dose group time capsule KLN late arrhythmia(P <0.05),while the KLN capsule low dose group,verapamil group also has delayed the emergence of arrhythmia trend,but after There was no significant statistical difference(P >0.05 ).Compared with the control group,pulse rate in KLN capsule three dose groups significantly slowed down,and showed a dose-dependent relationship Compared with the control group,KLN capsule high dose group significantly reduced arrhythmia score (P <0.05 ),while the low-dose group and KLN capsule verapamil group were no significant differences(Pand the control group >0.05 ).Conclusion:KLN capsule has an effect on exogenous free radical-induced arrhythmias,and can slow down pulse rate.Its efficacy is superior to verapamil.关键词
快律宁/心律失常/外源性自由基/离体药效学Key words
Fast-law capsule/arrhythmia/exogenous free radicals/vitro pharmacodynamics引用本文复制引用
于晓明,杨传华,陆峰..快律宁胶囊对外源性自由基所致心律失常的影响[J].中国现代中药,2015,(6):556-559,4.基金项目
［基金项目］国家科技重大新药创制专项课题---抗快速性心律失常中药候选新药研究 （）
