中医药学报Issue(3)：26-29,4.
参姜锁阳益气片对寒凝气滞血瘀证大鼠血清中6-keto-PGF1a、TXB2及氧自由基代谢的影响
Effects of Shenjiang Suoyang Yiqi Tablets on 6-keto-PGF1a, TXB2 in Serum and the Metabolism of Oxygen Free Radicals in Blood Stasis Due to Cold Accumulation and Stagnation of the Circulation of Vital Energy Model Rats
摘要
Abstract
Objective:To observe the effects of shenjiang Suoyang Yiqi tablets on 6-keto-PGF1a , TXB2 in serum and the metabolism of oxygen free radicals in blood stasis due to cold accumulation and stagnation of the circulation of vital energy model rats .Methods:The SD rats were randomly divided into normal group , model group , reagent ( Shenjiang Suoyang Yiqi tablet) high,medium,low dose groups and traditional Chinese medicine (Strains of Rhodiola capsule) control group .Except the normal group , the rest groups were established the blood stasis adrenaline and ice water bath composite low temperature freezing model in rats , each intragastric administration .The normal group and the model group Intragastric administration of the same volume of saline saline ,one time a day, for two consecutive weeks .After the last administration , the contents of 6-keto-PGF1a , TXB2 in serum were detected by radioimmunoassay and the activities of NOS,SOD, GSH -Px in serum were detected by chemical colorimetric method .Results: Compared with the model group, Shenjiang Suoyang Yiqi tablets low , medium, high dose groups could significantly reduce the contents of 6-keto-PGF1a, TXB2 in serum (P<0.01);In medium and high dose groups,the activities of SOD and GSH -Px in ser-um increased significantly (P<0.05,P<0.01);NOS activity in serum of high dose group was increased (P<0.05). Conclusion:Shenjiang Suoyang Yiqi tablets can control the 6-keto-PGF1a , TXB2 level of blood stasis due to cold ac-cumulation and stagnation of the circulation of vital energy model rats and can improve the oxygen free radical metabo -lism in model rats, which may be the mechanism of prevention and treatment of organs function decline in alpine envi -ronment.关键词
参姜锁阳益气片/寒凝气滞血瘀证/6-酮-前列腺素F1a/血栓素B2/氧自由基Key words
Shenjiang Suoyang Yiqi tablets/Blood stasis due to cold accumulation and stagnation of the circulation of vi-tal energy/6-keto-PGF1a/TXB2/Oxygen free radical分类
医药卫生引用本文复制引用
贾丹兵,于淼,李乃民,李春杰,唐立明,朱宇,刘珊,巩沅鑫,魏博..参姜锁阳益气片对寒凝气滞血瘀证大鼠血清中6-keto-PGF1a、TXB2及氧自由基代谢的影响[J].中医药学报,2014,(3):26-29,4.基金项目
国家科技重大专项基金 （）
