中医药学报Issue(3)：143-145,3.
柴胡加龙骨牡蛎汤对慢性应激抑郁大鼠海马BDNF表达的影响
Effects of Radix Bupleuri,Fossil Fragments and Oyster Soup on the Expression of Chronic Mild Stress Depression Rats’ Hippocampus
摘要
Abstract
Objective:To discuss the effects of radix bupleuri ,fossil fragments and oyster soup on the expression in chronic mild stress depression rats ’ hippocampus .Method:Randomly divide 50 SD male rats into five groups , 10 SD rats in each group, which were control group, depression model group(model group), low and high dose groups of radix bupleuri, fossil fragments and oyster soup , fluoxetine group .Chronic mild stress with solitary condition and immunohistochemistry was taken to establish model to observe the expression of the hippocampus BDNF in rats .Results:Expression of hippo-campus BDNF in depression model group was lower (P<0.05),radix bupleuri,fossil fragments and oyster soup could ease this variation to certain extent .The data in high dose group were similar to them in fluoxetine group ( P>0 .05 ) . Conclusion:Radix bupleuri ,fossil fragments and oyster soup can increase the expression of hippocampus BDNF in de -pression models .This may be one phrase in antidepression .关键词
柴胡加龙骨牡蛎汤/慢性应激/BDNFKey words
Radix bupleurifossil fragments and oyster soup/Chronic mild stress/BDNF分类
医药卫生引用本文复制引用
王晓滨,孙荣华,胡继平,孔明月,刘树民..柴胡加龙骨牡蛎汤对慢性应激抑郁大鼠海马BDNF表达的影响[J].中医药学报,2014,(3):143-145,3.基金项目
黑龙江省博士后资助经费资助项目 （）
