中医药学报Issue(4)：58-60,3.
三痹颗粒对 CIA 模型大鼠血清 CXCR3、CXCR4mRNA 的影响
Effect of Sanbi Granule on Serum CXCR3,CXCR4mRNA in CIA Model Rats
摘要
Abstract
Objective:To observe the effect of Sanbi granule on chemokine receptor of diseased joints in CIA model rats , and to discuss the anti -inflammatory mechanism .Methods:Divide CIA model rats randomly into a model group ,a high dose group ,a mid-dose group ,a low-dose group and a blank group .In high dose group ,mid-dose group and low -dose group model rats were given different doses of Sanbi granule distilled solution in primary immune on the 15th day. In model group and blank group model rats were given the same volume normal saline .All model rats were gavaged for 20 days.Observe model rats ’ swelling ankles and the arthritis index .Measure the contents of CXCR 3 and CXCR4 in model rats with RT -PCR method.Results:Compared with blank group on the 2lst day, in model group and Sanbi granule groups the model rats ’ feet were all increased in volume .The difference had a statistical significance ( P<0 .05 ) .Com-pared with model group on the 35th day,the rising degree of model rats ’ feet volume in Sanbi granule groups slowed down .And in these groups the degree of joint inflammation was reduced .The difference had a statistical significance ( P<0.05 ) .Compared with model group ,the arthritis index of Sanbi granule groups was decreased sharply .The differ-ence had a statistical significance (P <0.05).Compared with model group,the expressions of CXCR3mRNA,CX-CR4mRNA of model rats ’ peripheral blood in Sanbi granule groups were decreased obviously .The difference had a sta-tistical significance(P<0.05).Conclusion:Sanbi granule can restrain the expressions of CXCR 3,CXCR4 of peripheral blood in CIA model rats ,make the rising degree of model rats ’ feet volume to slow down ,decrease arthritis index and re-strain inflammatory reaction .关键词
三痹颗粒/CIA模型大鼠/CXCR3/CXCR4Key words
Sanbi granule/CIA model rats/CXCR3/CXCR4分类
医药卫生引用本文复制引用
张春芳,汪洋,王炎焱,赵志诚,客蕊,陈会君,徐峰..三痹颗粒对 CIA 模型大鼠血清 CXCR3、CXCR4mRNA 的影响[J].中医药学报,2014,(4):58-60,3.基金项目
2011年度黑龙江省教育厅课题 （）
