中医药学报Issue(4)：92-94,3.
护肝调脂方对非酒精性脂肪性肝炎血清及肝组织瘦素、脂联素影响的实验研究
Experimental Research on the Effect of Hugan Tiaozhi Decoction on Serum and Liver Tissue Leptin and Adiponectin of Nonalcoholic Steatohepatitis
摘要
Abstract
Objective: To research the effect of Hugan Tiaozhi decoction on serum and liver tissue leptin and adiponectin of nonalcoholic steatohepatitis.Methods:102 male rats were randomly divided into a normal control group (n =20),a model group(n =22), Hugan Tiaozhi decoction high (n =20), medium(n =20) and low (n =20) dose groups.The rats in control group were fed with basic diet ,and the rest in other four groups were set up by adopting the improved high -fat diet to copy NASH rat models,and at the same time they were given Hugan Tiaozhi decoction intervention . Observe the general condition, measure body weight and liver weight of the rats , determine ALT,AST,TC,TG with auto-matic biochemical analyzer, liver homogenate and biochemical determination of leptin and adiponectin levels .Results:The leptin levels in serum and liver tissue of the model group were significantly increased and the adiponectin level was decreased significantly(P <0.01).But the leptin levels in serum and liver tissue of Hugan Tiaozhi decoction group were significantly decreased and the adiponectin level was increased significantly (P <0.01).The medium dose group and low dose group were statistically significant (P <0.05), and the high dose group and the medium dose group had no statistical difference(P >0.05) .Conclusion: Leptin and adiponectin play an important role in rats with NASH .Hugan Tiaozhi decoction has an obviously therapeutic effect on rats with NASH .The mechanism may be related to regulating the levels of leptin and adiponectin on serum and liver tissue .关键词
非酒精性脂肪性肝炎/护肝调脂方/瘦素/脂联素Key words
Nonalcoholic steatohepatitis/Hugan Tiaozhi decoction/Leptin/Adiponectin分类
医药卫生引用本文复制引用
崔淑玫,赵莹,蔡宏宇,郑小平..护肝调脂方对非酒精性脂肪性肝炎血清及肝组织瘦素、脂联素影响的实验研究[J].中医药学报,2014,(4):92-94,3.基金项目
黑龙江省卫生厅科研课题项目 （）
