中医药学报Issue(1)：15-18,4.
消石利尿化瘀法对高尿酸血症大鼠血清 UA、NO、ET－1、TXB2及6－keto－PGF1 a的影响
Effect of Expelling Stone,Dieresis and Removing Stasis Method on UA,NO,ET-1, TXB2 and 6-keto-PGF1 a in Serum of Hyperuricemia Rats
摘要
Abstract
Objective:To investigate the uric acid (UA),nitric oxide (NO),Endothe lin-1 (ET-1),Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1a (6-keto-PGF1a) in the rats with Hyperuricemia by Chinese herbal com-pound prescription,which is based on the traditional therapies of expelling stone,diuresis and removing stasis.Investigate the mechanism and its protective effect on vascular endothelial cells (VEC).Methods:Male SD rats were randomly di-vided into a normal group,a model group,a Benzbromarone group,a high medium and a low-dose Chinese herbal com-pound preseription ( HC,MC and LC) group in three doses.In addition to the normal group,the rest were offered with Adenine and Yeast extracts for 21 days.While the appropriate drugs were administered to the rats in the administration groups,and the normal group and the model group were given by the gavage distilled water for 21 days.Then blood was collected,the UA and NO contents in serum were determined by ultraviolet–visible spectroscopy,and the ET-1,TXB2 and 6-keto-PGF1a contents in serum were detected by radiommunoassay.Results:The levels of UA,ET-1,TXB2 in the model group compared with the normal group were significantly increased (P<0.05).The levels of NO,6-keto-PGF1a in the model group compared with the normal group were significantly decreased (P<0.05).Compared with the model group,the concentrations of UA,ET-1 and TXB2 were evidently decreased in serumin MC group of the treated rats ( P<0.01) .Compared with the model group,the concentrations of NO and 6-keto-PGF1a in each Chinese herbal compound prescription group were evidently increased in serum(P<0.01).Conclusion:The Chinese herbal compound prescription which is based on the traditional therapies of expelling stone,diuresis and removing stasis can decrease the uric acid contents and protect the function of vasomotor.关键词
高尿酸血症/UA/NO/ET-1/TXB2/6-keto-PGF1a/消石利尿化瘀法Key words
Hyperuricemia/UA/NO/ET-1/TXB2/6-keto-PGF1a/Expelling stone,diuresis and removing stasis分类
医药卫生引用本文复制引用
郑媛,张建军,王淳,王林元,杨旭,刘畅..消石利尿化瘀法对高尿酸血症大鼠血清 UA、NO、ET－1、TXB2及6－keto－PGF1 a的影响[J].中医药学报,2015,(1):15-18,4.基金项目
国家自然科学基金项目 （）
