中医药信息Issue(2)：40-43,4.
音乐电针对SAMP8小鼠行为学及大脑皮层NEP、IDE表达的影响
Effect of Music Electro-acupuncture Intervention on the Behavior and the Expression of NEP and IDE in Cerebral Cortex of SAMP8
摘要
Abstract
Objective:To observe the influence of music electro -acupuncture ( EA ) on the behavior and the expression of NEP and IDE in cerebral cortex of SAMP 8, so as to explore its mechanism underlying relief of Alzheimer’s Disease(AD).Methods:SAMP8 mice were randomly divided into model , medication and music EA groups.SAMR1 mice were used as the control group .Mice of the medication group were treated by oral administration of donepezil(0.92mg/kg).Music EA was applied to “Baihui”(GV20) and “Yintang”(EX-HN3) for 20min, and then swift pricked “Shuigou”(GV26).The learning memory ability of mice was detec-ted by using Morris Water Maze .The expression levels of NEP and IDE in cerebral cortex were assayed by im-munohistochemistry .Results:Compared with the model group , the learning memory ability of the music EA group improved obviously as well as the medication group ( P>0 .05 );The expression levels of NEP and IDE in cerebral cortex were increased obviously ( P<0 .05 ) .Conclusion:Music EA can effectively improve learning memory ability of SAMP8 mice which may be closely associated with their effects on improving the expression of NEP and IDE in cerebral cortex .关键词
阿尔茨海默病/音乐电针/中性内肽酶/胰岛素降解酶Key words
Alzheimer ’ s disease/Music eletro-acupuncture/Neprilysin/Insulin degrading enzyme分类
医药卫生引用本文复制引用
许安萍,李志刚,唐银杉,莫雨平,姚海江,赛因朝克图..音乐电针对SAMP8小鼠行为学及大脑皮层NEP、IDE表达的影响[J].中医药信息,2014,(2):40-43,4.基金项目
国家自然科学基金项目 （）
