中医药信息Issue(2)：44-47,4.
电针对慢性强迫游泳应激模型大鼠抑郁样行为及血清5-HT的影响
Effects of Electroacupuncture on Depressive-like Behavior and Serum 5-HT in the Chronic Forced Swim Stress Model Rats
摘要
Abstract
Objective:To observe the effects of electroacupuncture ( EA) on depressive-like behavior and ser-um 5-hydroxytryptamine (5-HT) of the chronic forced swim stress model rats .Methods:40 male SD rats were evenly randomized into normal control , model, fluoxetine and EA groups .The chronic stress rat model was established by chronic forced swim .The behaviors were evaluated by body weight , open field test and su-crose intake test , the serum 5-HT was detected by ELISA .Results: Compared with the control group , the body weight , crossings and rearings in the open field test , the sucrose intake , and the serum 5-HT of model group were decreased significantly (P<0.05).Compared with the model group , the body weight, crossings and rearings in the open field test , the sucrose intake , and the serum 5-HT of fluoxetine group and EA group were all increased significantly (P<0.05).But there was no significant difference between EA group and flu-oxetine group (P>0.05).Conclusion:Electroacupuncture can improve the model rats ’ depressive-like be-haviors which are caused by chronic forced swim stress , and may increase the serum 5-HT of the model rats . Hereby , electroacupuncture may have anti -depressive effects .关键词
电针/强迫游泳/抑郁样行为/血清5-HTKey words
Electroacupuncture/Forced swimming/Depressive-like behavior/Serum 5-HT分类
医药卫生引用本文复制引用
包伍叶,宋英周,卢峻,任英贞,李伊朔,图娅,郭卓,孙岚..电针对慢性强迫游泳应激模型大鼠抑郁样行为及血清5-HT的影响[J].中医药信息,2014,(2):44-47,4.基金项目
国家自然科学基金资助项目（No．81173334／H2718）；高等学校博士点课题 （）
