中医药信息Issue(3)：53-55,3.
苓桂术甘汤对心肌缺血再灌注损伤 SOD、MDA含量的影响
Effect of Linggui Zhugan Decoction on SOD, MDA Caused by Myocardial Ischemia-reperfusion Injury
摘要
Abstract
Objective:To study the effects of Linggui Zhugan decoction on SOD and MDA caused myocardial is-chemia-reperfusion injury in rabbits and explore the mechanism of its possible protection to ischemia -reper-fusion injury in the level of biochemistry .Methods: Forty rabbits were randomly divided into blank , model, sham, high-dose, low-dose groups.Myocardial ischemia-reperfusion injury models of rabbits were estab-lished by ligating the left descend coronary artery .After ischemia 40 minutes and reperfusion for three hours , examine the amount of SOD and MDA in the serum .Results: Compared with model group after ischemia 40 minutes, SOD in high-dose group was higher , MDA in high-dose group was significantly lower .SOD in high-dose group was significantly higher and MDA was significantly lower after reperfusion for three hours ;SOD in low-dose group had no obvious change;MDA was significantly lower after ischemia 40 minutes and after reperfusion for three hours respectively .Compared with low-dose group , SOD in high-dose group was higher and MDA was lower .Conclusion:Linggui Zhugan decoction has a protective effect on myocardial ische-mia-reperfusion injury models of rabbits;the mechanism may be related to the increase of SOD activity and to the reduction of excessive production of MDA , and high -dose group is more effective than low -dose group.关键词
苓桂术甘汤/再灌注损伤/SOD/MDAKey words
Linggui Zhugan decoction/Reperfusion injury/SOD/MDA分类
医药卫生引用本文复制引用
康天济,韩宇博,田苗,郭维毅,周彬彬,于丽楠,田明..苓桂术甘汤对心肌缺血再灌注损伤 SOD、MDA含量的影响[J].中医药信息,2014,(3):53-55,3.基金项目
黑龙江中医药大学大学生课外科技活动实验研究项目资助 （）
