中医药信息Issue(4)：4-7,4.
芥子碱氯化盐对家兔离体肠平滑肌收缩功能的影响
Effect of Sinapine Chloride on the Contractility of Isolated Ileum Smooth Muscle of Rabbits
摘要
Abstract
Objective:To investigate the effect of sinapine chloride on the contractility of isolated ileum smooth muscle of rabbits .Methods:Use the contraction frequency and tension of muscle strips as indexes to investigate the effect of different doses of sinapine chloride on the contractility of isolated ileum smooth muscle , and the contraction information was recorded with Medlab -U/4 C501 H biological function experimental system .The muscle strips were incubated with M receptor blocker ( atropine ) to observe the effects of sinapine chloride con-tractile activity in the presence of atropine .Results:All doses of sinapine chloride had no obvious effect on the contraction frequency of isolated ileum smooth muscle strips ( P>0 .05 ) .All doses of sinapine chloride could obviously increase the tension of muscle strips ( P<0 .01 ) .M receptor blocker ( atropine ) could inhibit the contraction effect caused by Sinapine but the effect was incomplete .Conclusion:Sinapine chloride has an ex-citatory effect on the contractility of isolated ileum smooth muscle and the effect is related to the M receptor .关键词
芥子碱氯化盐/离体肠平滑肌/M受体Key words
Sinapine chloride/Isolated ileum smooth muscle/M receptor分类
医药卫生引用本文复制引用
刘世超,卢轩,冯宝民,郑学仿,张宁,王惠国..芥子碱氯化盐对家兔离体肠平滑肌收缩功能的影响[J].中医药信息,2014,(4):4-7,4.基金项目
国家自然科学基金项目（No．31201336）；大连市科技计划项目 （）
