中医药信息Issue(4)：126-129,4.
慢性束缚应激对大鼠睡眠时相的影响及酸枣仁汤的干预作用
Effect of Chronic Restraint Stress on Rats’ Sleep Phase and Intervention of Suanzaoren Decoction
摘要
Abstract
Objective:To investigate the effect of chronic restraint stress on rats ’ sleep phase and the interven-tion of Suanzaoren decoction .Methods:In this research , chronic restraint stress method was used to establish the model of chronic mild stress in rats .EEG and EMG of rats were monitored by the polygraph for 12h, in or-der to analyze the duration and percentage proportion in total sleep time of each sleep phase .The intervention of Suanzaoren decoction on sleep phase was also investigated .Results: Compared with the blank group , the duration of total sleep time ( TST ) , light sleep ( LS ) , slow wave sleep ( SWS ) and rapid eye movement (REM) sleep of rats in model group were significantly decreased (P<0.05).The percentage proportion of LS in TST was significantly raised and SWS was reduced markedly ( P<0 .05 ) , while REM was changed slightly . Compared with model group , duration of TST , LS and SWS of rats in administrated group were significantly in-creased(P<0.05).Though there was a porlonged trend on REM sleep , the ANOVA did not show signifi-cance(P>0.05).The percentage proportion of SWS in TST was raised markedly (P<0.05).Though there was a reduced trend on LS and REM sleep , no significance was detected by ANOVA ( P>0 .05 ) .Conclusion:The sleep structure of rats was disturbed by chronic restraint stress .Suanzaoren decoction;Suanzaoren decoc-tion could effectively alleviate the impact of chronic restraint stress on sleep .关键词
慢性束缚应激/大鼠皮层脑电描记技术/睡眠时相/EEG/EMG/酸枣仁汤Key words
Chronic restraint stress/Cortical EEG monitoring technology/Sleep phase/EEG/EMG分类
医药卫生引用本文复制引用
张斌,张乔,马英男..慢性束缚应激对大鼠睡眠时相的影响及酸枣仁汤的干预作用[J].中医药信息,2014,(4):126-129,4.基金项目
黑龙江省博士后科研基金资助项目 （）
