中医药信息Issue(3)：3-8,6.
菊苣提取物对高甘油三酯并高尿酸血症模型大鼠肠道菌群的影响
Effect of Chicory Extracts on Gut Flora of Hypertriglyceride in Hyperuricemia Rat Models
摘要
Abstract
Objective:To investigate the effect of chicory extracts on serum UA,TG and TC levels of hypertrig-lyceride in hyperuricemia rats induced by high fructose water,to discuss the possible characteristics of chicory extracts from the respect of gut flora.Methods: Male SD rats were randomly divided into 6 groups,a normal group,a control group, chicory groups with high and low doses, a fenofibrate group and a benzbromarone group.The normal group was given distilled water,and other groups were given 10%fructose water.Biochem-ical technique was used to detect serum UA,TG and TC levels,and gut flora macrostructure was analyzed by ERIC-PCR fingerprint.Results:Compared with the normal group, TG level in the control group significantly increased on the 7th day;TG level increased significantly,and UA level had the trend to increase on the 14th day;TG and UA levels increased simultaneously on the 21st day,and it showed that the rat models of hyper-triglyceride with hyperuricemia were established successfully.Compared with the control group,in the chicory groups with high and low doses,in the fenofibrate group and in the benzbromarone group UA level decreased significantly on the 14th day;in the chicory group with high dose TG and UA levels significantly decreased,and the chicory group with low dose had the trend to decrease TG and UA levels;in the fenofibrate group TG level decreased significantly and in the benzbromarone group UA level decreased significantly.ERIC-PCR finger-print revealed that compared with the normal group, the gut flora structure in the control group changed signifi-cantly,and in the meanwhile chicory groups with high and low doses could interfere the disordered gut flora. Conclusion:The effect of chicory extracts on hypertriglyceride with hyperuricemia is significant.In addition, it can improve disordered gut flora.It reveals that chicory extracts may work by changing gut flora in rats,but the specific mechanism remains to be further researched.关键词
菊苣提取物/高尿酸/高甘油三酯/肠道菌群/ERIC-PCRKey words
Chicory extracts/Hyperuricemia/Hypertriglyceride/Gut flora/ERIC-PCR分类
医药卫生引用本文复制引用
王红坡,张冰,林志健,孙博喻,牛红娟,朱春胜,王雪洁..菊苣提取物对高甘油三酯并高尿酸血症模型大鼠肠道菌群的影响[J].中医药信息,2015,(3):3-8,6.基金项目
教育部高等学校博士学科点专项科研基金项目（No．20130013120001，20120013130002）；北京中医药大学青年教师专项自主课题（No．2013－QNJSZX008）；北京中医药大学科研创新团队项目（No．2011－CXTD－014）；北京中医药大学自主选题项目 （）
