中医药信息Issue(4)：32-34,3.
熟地黄多糖诱导 H22荷瘤小鼠细胞凋亡作用的研究
Research on the Effect of RPS on Cell Apoptosis of H22 tumor-bearing mice
摘要
Abstract
Objective:To investigate RPS vivo anti-tumor mechanism of induction of apoptosis of tumor cells, the impact of Bcl-2 protein expression and apoptotic morphological changes,and to provide the basis for clini-cal application.Methods:The H22 ascites mice were inoculated with tumor strain, and the preparation models were divided into the saline group,the cyclophosphamide group and the RPS group.Immunohistochemistry was used to detect tumor tissue Bcl-2 protein expression and apoptosis by TUNEL index.Results:Compared with the model group,Bcl-2 protein mean optical density in the RPS group was lower,and the difference was sig-nificant(P<0.01).The apoptotic index in the RPS group increased significantly(P<0.05).Conclusion:RPS can inhibit the H22 tumor tissue expression of Bcl-2 in mice,so the number of apoptotic cells increases signifi-cantly,and RPS can effectively induce apoptosis in tumor-bearing mice.关键词
熟地黄多糖/细胞凋亡/Bcl-2/TUNEL法Key words
RPS/Apoptosis/Bcl-2/TUNEL分类
医药卫生引用本文复制引用
董静,吴勃岩,车艳新,梁颖,王雪,李明珠..熟地黄多糖诱导 H22荷瘤小鼠细胞凋亡作用的研究[J].中医药信息,2015,(4):32-34,3.基金项目
黑龙江中医药中青年科技攻关项目 （）
