组织工程与重建外科杂志Issue(3)：145-148,4.DOI:10.3969/j.issn.1673-0364.2014.03.006
机械张力诱发小鼠增生性瘢痕的实验研究
Experimental Study on Hypertrophic Scar Model Initiated by Mechanical Load
摘要
Abstract
Objective To demonstrate whether scars initiated by mechanical load were visually and histopathologically identical to human hypertrophic scars. Methods A 2 cm linear full-thickness incision was made on the dorsum of the mouse. On postoperative day 4, tension on the wounds was created and lasted for 2 weeks. Macroscopic and histological characteristics were examined at day 1, 30, 60 after traction, respectively. The changes of scararea, velative collagen density and cellulartty were cal;culated. Results Resulting scars were structurally identical to human hypertrophic scars and were persisted for more than 60 days. However, area of scars was gradually shrinking. Conclusion Hyperthophic scar in animal model could be initiated by mechanical load.关键词
机械张力/增生性瘢痕/毛囊再生Key words
Mechanical load/Hypertrophic scars/Hair follicle regeneration分类
医药卫生引用本文复制引用
温从吉,傅士博,周仁鹏,王丹茹..机械张力诱发小鼠增生性瘢痕的实验研究[J].组织工程与重建外科杂志,2014,(3):145-148,4.基金项目
上海市科委项目（12140904100）；浦江人才计划（10PJD008）。 （）
