组织工程与重建外科杂志Issue(6)：314-317,4.DOI:10.3969/j.issn.1673-0364.2014.06.004
脐带间充质干细胞治疗多系统萎缩小脑型的安全性及疗效研究
Effectiveness of Umbilical Cord Mesenchymal Stem Cells in Treating Multiple System Atrophy-Cerebellar Type
摘要
Abstract
Objective To observe the effectiveness of intrathecal injection with umbilical cord mesenchymal stem cells (UC-MSCs) in treating multiple system atrophy-cerebellar type (MSA-C). Methods From December 2009 to April 2012, 40 patients with MSA-C were given UC-MSCs intrathecal injection with the dosage of 1 ×106 cells/Kg for once a week, 4 times as a course. Twenty-nine patients were treated with 1 course, 9 patients with 2 courses and 2 patients with 3 courses. International Cooperative Ataxia Rating Scale (ICARS) and Activity of Daily Living Scale (ADL) were used to evaluate patients' neural function and ability of daily living. Patients were followed up after treatment. Results In 53 courses, 47 courses are effective (the effective rate was 88.68%). Compared with the ICARS and ADL scores before treatment, patients ’ scores were significantly decreased 1 month after treatment (P<0.01). In most effective cases, clinical symptoms such as unstable walking and standing, slow movement, upper limb fine motor disorder, writing difficulties, dysarthria, eye movement disorders were improved. During treatment, common adverse effects were observed, as dizziness (4 cases), low back pain (1 cases), headache (2 case) and fever (2 cases), all these symptoms disappeared within 1-3 days. No treatment-related adverse events were observed during 27-55 months (median 40 months) of follow-up. The stable effective period of patients ws 2-13 months (average 5.88 ±2.86 months), then progressed. Conclusion UC-MSCs intrathecal injection is safe, and can ameliorate clinical symptoms to some extent. Multiple courses of treatment can further improve neurological function and delay illness progression in most patients.关键词
脐带间充质干细胞/多系统萎缩/鞘内注射Key words
Umbilical cord mesenchymal stem cells/Multiple system atrophy/Intrathecal injection分类
生物科学引用本文复制引用
刘静,郭子宽,王恒湘,韩冬梅,丁丽,薛梅,王志东,阎洪敏,朱玲,郑晓丽,董磊..脐带间充质干细胞治疗多系统萎缩小脑型的安全性及疗效研究[J].组织工程与重建外科杂志,2014,(6):314-317,4.基金项目
首都发展基金项目（2007-2033）；国家高新技术研究发展计划（863项目，2007AA022454）；国家重大新药创制基金（20092x09503-019）；军队临床高新技术重大项目（2010gxjs049）。 （）
