动物医学进展Issue(8)：24-27,4.
α-硫辛酸对 Marc-145细胞感染高致病性猪繁殖与呼吸综合征病毒后氧化应激的影响
Effects ofα-lipoic Acid on Oxidative Stress of Marc-145 Cells Infected with HP-PRRSV
摘要
Abstract
To study the effect of Highly pathogenic PRRSV (HP-PRRSV)on antioxidant function of Marc-145 cells and the effect ofα-lipoic acid(LA)on oxidative stress of Marc-145 cells infected with HP-PRRSV.After LA within cellular safety concentration was added to Marc-145 cells infected with HP-PRRSV,the Marc-145 cells were divided into three groups of virus-infected (group D),LA-treated-virus (group DLA)and LA-add(group LA).The normal Marc-145 cells were served as the control(group NC). The levels of hydrogen peroxide (H2 O2 ),malondialdehyde(MDA)and the activity of superoxide dismutase (SOD),catalase(CAT)were detected 2 hours later.Compared with group NC,the levels of H 2 O2 and MDA were significantly elevated (P <0.05),and the activities of SOD and CAT were significantly reduced in group D (P <0.05).All markers above were improved by treatment with LA (P <0.05).HP-PRRSV can cause Marc-145 cell high oxidative stress,and LA has a protective effect on Marc-145 cell through in-hibiting oxidative stress.关键词
高致病性猪繁殖与呼吸综合征病毒/Marc-145 细胞/氧化应激/α-硫辛酸Key words
Highly pathogenicity porcine reproductive and respiratory syndrome virus/Marc-145 cells/oxi-dative stress/α-lipoic acid分类
农业科技引用本文复制引用
张浩,胡莲美,邱先帅,肖熹玉,任常宝,唐兆新..α-硫辛酸对 Marc-145细胞感染高致病性猪繁殖与呼吸综合征病毒后氧化应激的影响[J].动物医学进展,2015,(8):24-27,4.基金项目
国家自然科学基金项目 （）
