动物医学进展Issue(8)：64-66,67,4.
大蒜新素减少 Rac1／Cdc42、MMP2表达抑制 Hela 细胞转移能力的研究
Allicin Inhibits Metastasis of Hela Cells By Down-regulating Expression of Rac1/Cdc42 and MMP2
摘要
Abstract
To investigate the possible mechanism that allicin inhibits Hela cell metastasis,Hela cells were treated with allicin(100 μmol/L).The expressions of Rac1 and Cdc42 proteins were detected by Western blot.The expression of MMP2 mRNA was detected by semi-quantitative RT-PCR method.The expres-sions of Rac1 and Cdc42 in Hela cells treated with allicin were remarkably down-regulated(P <0.05),and the expression of MMP2 mRNA also decreased significantly (P <0.01).The inhibition of Hela cell metas-tasis by allicin may be closely related to changes in expressions of Rac1/Cdc42,MMP2.关键词
大蒜新素/Hela细胞/转移Key words
allicin/Hela cell/metastasis分类
生物科学引用本文复制引用
宋旭日,胡静,张松波,郭中奎,滕淑静..大蒜新素减少 Rac1／Cdc42、MMP2表达抑制 Hela 细胞转移能力的研究[J].动物医学进展,2015,(8):64-66,67,4.基金项目
湖南省教育厅科研项目 （）
