国际医药卫生导报2015，Vol.21Issue(16)：2371-2374,4.DOI:10.3760/cma.j.issn.1007-1245.2015.16.020
不同剂量新鲜冰冻血浆治疗肝硬化腹水的临床观察
Clinical observation of different doses of fresh frozen plasma in the treatment of ascites due to liver cirrhosis
付昕 1马春玲 2陈艳清 1李婉葵 1冯梅华1
作者信息
- 1. 523721 东莞市塘厦医院检验科
- 2. 523721 东莞市塘厦医院肝病专科
- 折叠
摘要
Abstract
Objective To observe the clinical curative effect and adverse reaction of different doses of fresh frozen plasma (FFP) in the treatment of ascites due to liver cirrhosis.Methods 90 patients with ascites due to liver cirrhosis were randomly divided into low dose of FFP group (5 ml/kg),middle dose of FFP group (10 ml/ kg) and high dose of FFP group (15 ml/kg),30 cases in each group.Different doses of FFP were mainlined in three groups on the basis of a unified scheme.The course of treatment lasted 2 weeks.Blood coagulative function,the overall effect and adverse reaction were observed in three groups before and after treatment.Results After treatment,PT,APTT and INR decreased in all three groups,while FIB increased.Curative effect of middle dose group and high dose group were better than that of low dose group (P＜0.05),while there was no statistically significant difference in curative effect between middle dose group and high dose group (P＞0.05).The total effective rate was 53.33％ in low dose group,80.00％ in middle dose group,83.33％ in high dose group.The total effective rate of middle dose group and high dose group were better than that of low dose group,while there was no statistically significant difference in the total effective rate between middle dose group and high dose group.There was no obvious adverse reaction in low dose group or middle dose group;1 case of mild allergic reaction and 1 case of fever reaction occurred in high dose group.Conclusion FFP at the dose of 10 ml/kg was more effective than that at the dose of 5 ml/kg,with less adverse reaction.关键词
新鲜冰冻血浆/剂量/肝硬化腹水/疗效/不良反应Key words
Fresh frozen plasma/Dose/Ascites due to liver cirrhosis/Clinical curative effect/Adverse reaction引用本文复制引用
付昕,马春玲,陈艳清,李婉葵,冯梅华..不同剂量新鲜冰冻血浆治疗肝硬化腹水的临床观察[J].国际医药卫生导报,2015,21(16):2371-2374,4.
