郑州大学学报（医学版）Issue(4)：477-481,5.DOI:10.13705/j.issn.1671-6825.2015.04.007
不同频率重复经颅磁刺激对慢性应激抑郁模型大鼠行为的影响∗
Effect of different frequency repetitive transcranial magnetic stimulation on depression-like behavior for chronic stress depression model rats
摘要
Abstract
Aim: To explore the behavioral changes of chronic stress depression model rats given different frequency repetitive transcranial magnetic stimulation(rTMS) intervention. Methods: Forty adult male SD rats were allocated into normal control group(n = 8) and model preparation group(n = 32) randomly after screening. The rats in model preparation group were singly housed and given chronic unpredictable mild stress(CUMS) to build depression model. The rats in model preparation group were then allocated into 4 groups: model group(n = 8,without giving any treatment), high frequency group(n = 8,with the intervention of 10 Hz rTMS), low frequency group(n = 8,with the intervention of 1 Hz rTMS) and sham group(n = 8,simulation of rTMS environment without rTMS stimulus). The changes of behaviors in each group were detected by weight measurement, sucrose consumption test and open-field test. Results: There were significant differences in the weight reduction rate, sucrose consumption and the score of open field test among the 5 groups(F = 4. 091,7. 670, 11. 008, and 30. 316,P < 0. 05);compared with model group and sham group, the weight reduction rate, sucrose consump-tion and the score of open field test in high frequency group and low frequency group were higher(P < 0. 05),and the differ-ence between high frequency group and low frequency group was not significant(P > 0. 05). Conclusion: rTMS could im-prove the depression-like behavior in chronic stress depression model rats, and the improvement is basically identical be-tween high frequency rTMS stimulation and low frequency rTMS stimulation.关键词
抑郁症/重复经颅磁刺激/大鼠/行为学Key words
depression/repetitive transcranial magnetic stimulation/rat/behavior分类
医药卫生引用本文复制引用
张朝辉,赵琳,任慧聪..不同频率重复经颅磁刺激对慢性应激抑郁模型大鼠行为的影响∗[J].郑州大学学报（医学版）,2015,(4):477-481,5.基金项目
河南省医学科技攻关项目201203071 （）
