郑州大学学报（医学版）Issue(4)：522-525,4.DOI:10.13705/j.issn.1671-6825.2015.04.019
寻常型银屑病皮损组织中 Nestin、NF-κBp65及 STAT3蛋白的表达∗
Expressions of Nestin,NF-κBp65 and STAT3 in psoriatic lesion of pa-tients with psoriasis vulgaris
摘要
Abstract
Aim: To compare the expression levels of Nestin, NF-κBp65 and STAT3 in psoriatic lesions and normal samples. Methods: Immunohistochemical technique was used to determine the expressions of Nestin, NF-κBp65 and STAT3 in 14 psoriatic lesions and 14 normal samples. Results: The Nestin was located in the cytoplasm of respective stem cells in the basic cell layer, while that of NF-κBp65 or STAT3 was located in nuclei and cytoplasm in some basic layer cells and prickle layer cells. The expression levels of Nestin, NF-κB and STAT3 in psoriatic lesions were significantly higher than that in the normal samples [ Nestin(167. 51 ± 12. 93) vs (114. 38 ± 10. 85),NF-κBp65 (127. 48 ± 13. 87) vs (101. 27 ± 10. 15) and STAT3(196. 34 ± 10. 70) vs (124. 63 ± 19. 93), t = 12. 977,6. 288,and 13. 072,all P < 0. 001]. There was positive correlation between NF-κBp65 and STAT3 in psoriatic lesions and normal samples ( r = 0. 960 and 0. 829,P < 0. 001). Conclusion: The expression levels of Nestin,NF-κB and STAT3 are significantly higher in psoriatic lesion, and inhibiting their expressions may be valid manipulation for treatment of psoriasis vulgaris.关键词
Nestin/NF-κBp65/STAT3/银屑病Key words
Nestin/NF-κBp65/STAT3/psoriasis disease分类
医药卫生引用本文复制引用
王芳,李红文,郑乃刚,吴景兰..寻常型银屑病皮损组织中 Nestin、NF-κBp65及 STAT3蛋白的表达∗[J].郑州大学学报（医学版）,2015,(4):522-525,4.基金项目
河南省自然科学基金项目2011A520042 （）
