中医学报Issue(9)：1311-1314,4.DOI:10.16368/j.issn.1674-8999.2015.09.454
推拿对坐骨神经损伤大鼠背根神经节降钙素基因相关肽表达的影响
Effects of Massage on the Expression of Calcitonin Gene-Related Peptide in Dorsal Root Ganglion of Chronic Constriction Injury Rats
摘要
Abstract
Objective:To observe the effect of massage on calcitonin gene-related peptide(CGRP)expression of the dorsal root ganglion neurons after sciatic nerve injury(SNI). Methods:48 rats were randomly divided into normal group,control group,model group,model control group,massage group,SNI model. Used manipulation maneuver simulation for intervention. Observed pain threshold and pain tol-erance sensitivity scores of field change and L3 - 5 section on the right side of CGRP expression in dorsal root ganglia. Results:After building for 7 days,compared with normal group,the pain tolerance threshold,tolerance sensitivity scores and CGRP expression in dorsal root ganglia of model group rats were significantly higher(P ﹤ 0. 01). After massage therapy 20 times,compared with the model group, the pain tolerance threshold and tolerance sensitivity scores of massage group were significantly decreased(P ﹤ 0. 05). Compared with model group and model control group,the CGRP expression in dorsal root ganglia of massage group was increased significantly(P ﹤0. 01). Conclusion:Massage can improve the CGRP expression of the dorsal root ganglion neurons,participate in neurological damage repair process so as to eventually improve the function of the feeling of peripheral nerve injury in rats.关键词
推拿/坐骨神经损伤/降钙素基因相关肽/背根神经节/大鼠Key words
massage/sciatic nerve injury/calcitonin gene related peptide/dorsal root ganglion/rat分类
医药卫生引用本文复制引用
冼思彤,于天源,潘璠,鲁梦倩,吴剑聪,高玉峰,张林峰..推拿对坐骨神经损伤大鼠背根神经节降钙素基因相关肽表达的影响[J].中医学报,2015,(9):1311-1314,4.基金项目
国家自然科学基金资助项目（81373759）；北京市自然基金资助项目（7142097）；博士点基金资助项目 （）
