摘要
Abstract
Objective:To study the mechanism of acupoint injection and acupoint catgut embedding in protecting islet beta cell function. Methods:50 male SD rats were randomly divided into blank control group,model group,acupoint injection group and the acupoint catgut embedding group. The blank control group was fed with normal diet,the other three groups with high fat and high sugar diet for 4 weeks, and according to the weight of the 35mg·kg - 1 by intraperitoneal injection of STZ induced type 2 diabetic rats. The blank control group was injected with citrate buffer solution,acupoint catgut embedding group,bilateral Zusanli( ST36),Sanyinjiao(SP6),Weiwanxiashu (EX-B3)catgut embedding,acupoint injection of Shenmai injection in acupoint injection were the same,once every other day,a total of 4 weeks. Observed the level of blood glucose,islet morphology and pander,Caspase-3 protein. Results:The fasting blood glucose of acu-point catgut embedding therapy group and acupuncture point injection group was significantly lower than that of model group( P ﹤0. 05),acupoint injection group decreased more significantly. The acupoint catgut embedding therapy group and acupuncture point in-jection group in pancreas islet cell damage was less than the model group(P ﹤ 0. 05),acupoint injection group islet cells even less. Compared with the blank group,model group increased expression of pander and Caspase-3 protein expression in the pancreas;acupoint catgut embedding group and acupoint injection group pander protein in pancreas decreased compared with the model control group,acu-puncture point injection group decreased more significantly. Conclusion:Acupoint injection and acupoint catgut embedding therapy may inhibit high glucose on islet beta cells of pander activation and Caspase-3 expression by lowering blood glucose,reduce the apoptosis of islet beta cell,alleviate the progression to type 2 diabetes,and acupoint injection improved the function of islet beta cells is more signifi- <br> cant.关键词
穴位埋线/穴位注射/2 型糖尿病/pander/Caspase-3/大鼠Key words
acupoint catgut embedding therapy/acupoint injection/type 2 diabetes/pander/Caspase-3/rat分类
医药卫生
