化工学报Issue(8)：2846-2853,8.DOI:10.11949/j.issn.0438-1157.20150948
高分子大孔微球的制备和结构控制
Preparation and structure control of macroporous polymer microspheres
摘要
Abstract
Formation and structure control of macroporous microsphere is a complex process. Special techniques were developed for the preparation of gigaporous microspheres with large pore size over 100 nm. To meet the needs of gigaporous microsphere in biochemical engineering, the reverse micelles swelling method and the multiple emulsion method were developed which achieved the control of pore diameter above 100 nm. The effects of microsphere structures on their applications were also studied. When used in separation and purification of biomacromolecule, the gigaporous microspheres showed much higher capacity, activity recovery and purification fold. Immobilized enzymes in gigaporous microsphere also have some significant advantages in thermal stability, storage stability and reusability. The effective control of the microsphere structure is important for success application in different fields.关键词
大孔微球/结构控制/药物缓控释/分离纯化Key words
macroporous microsphere/structure control/drug controlled release/separation and purification分类
化学化工引用本文复制引用
周炜清,李娟,那向明,马光辉..高分子大孔微球的制备和结构控制[J].化工学报,2015,(8):2846-2853,8.基金项目
国家自然科学基金项目（21336010）；国家高技术研究发展计划项目（2012AA02A406，2012AA021505）。 （）
