中国当代医药Issue(20)：50-53,56,5.
局部晚期直肠癌新辅助治疗中CEA、CA199的变化及临床意义
Changes and clinical significance of CEA and CA199 in the new adjuvant therapy of local advanced rectal cancer
摘要
Abstract
Objective To study the expression and changes of tested values of CEA and CA199 in the pre-operative new adjuvant therapy for patients with local advanced rectal cancer,and to analyze their clinical significance in curative effects and prognosis analysis of the new adjuvant therapy. Methods 66 patients with local progressive middle and low-er rectal cancer who were admitted to Department of Radiotherapy in Shanxi Tumor Hospital from September 2013 to September 2014 were retrospectively analyzed.According to the TNM staging method co-initiated by UICC and AJCC:among 66 patients,19 patients were in stage II,37 patients were in stage Ⅲ and 10 patients were in stage Ⅳ.Prior to and after the new adjuvant therapy,the patients were all given the test of CEA and CA199 level,and were all given re-lated imaging tests such as CT or MRI.Postoperative pathological results were evaluated according to TRG grading cri-teria of pathological regression.66 patients were all given new adjuvant therapy (concurrent radiochemotherapy before the surgery) for 4-8 weeks before receiving surgery. Results Expression of CEA and CA199 levels was significantly dif-ferent in clinical staging (P<0.01);expression of CEA and CA199 was not correlated with local advanced rectal cancer (P>0.05);after the completion of new adjuvant therapy,CEA and CA199 levels significantly reduced compared to those before the therapy (P<0.01);serum CEA level before the new adjuvant therapy was an important factor influencing the treatment outcome (P<0.05). Conclusion CEA and CA199 are of great clinical significance in the judgement of curative effects and assessment of disease conditions for pa-tients with local advanced rectal cancer receiving pre-operative concurrent radiochemotherapy and new adjuvant therapy.关键词
直肠癌/新辅助治疗/CEA/CA199/疗效评价Key words
Rectal cancer/New adjuvant therapy/CEA/CA199/Assessment of curative effects分类
医药卫生引用本文复制引用
任俊丽,樊卫平,韩存芝,韩晓栋,刘楷东..局部晚期直肠癌新辅助治疗中CEA、CA199的变化及临床意义[J].中国当代医药,2015,(20):50-53,56,5.基金项目
山西省肿瘤医院院级基金 （）
