中国当代医药Issue(21)：7-9,3.
活血润肠软胶囊对急性血瘀模型大鼠血液流变学的影响
Effect of Huoxue Runchang Soft Capsule on hemorheology in rat model of acute blood stasis and mesenteric microcirculation
郭金甲 1党晓伟 2李君 3张广兴 1王春民 2刘洋1
作者信息
- 1. 颈复康药业集团有限公司，河北承德 067000
- 2. 河北省中药新辅料工程技术研究中心，河北承德 067000
- 3. 承德护理职业学院，河北承德 067000
- 折叠
摘要
Abstract
Objective To observe the effect of Huoxue Runchang Soft Capsule on hemorheology in rat model of acute blood stasis and mesenteric microcirculation. Methods Ninety-eight experimental rats were divided into seven groups at random,namely the normal control group,the urgent blood stasis syndrome group,Tongbianling Capsule group (A) [0.134 g/(kg·d)],Aspirin Enteric-coated Tablets group (B) [0.05 mg/(kg·d)],low dose group (1.25 g crude drug/kg),mid-dle dose group (2.5 g crude drug/kg) and large dose group (5.0 g crude drug/kg) of Huoxue Runchang Soft Capsule.All drugs were administrated by intragastric administyrtion according to the weight of rats.The normal control group and the urgent blood stasis syndrome group were given an equal volume of normal saline.Other groups were orally administrated with Huoxue Runchang Soft Capsule for 7 days.The urgent blood stasis syndrome model was prepared by all rats but the normal control group and the urgent blood stasis syndrome group. Rats were cured by abrosia for 18-24 h in 7 days an hour later after adiministrating.The hemorrheo-logical parameters were tested. Results The levels of whole blood viscosities was significantly lower in the normal control group than that in the model control group (P<0.01).The levels of the lower,middle and higher tangential variation rates of the viscosity of the whole blood were significantly lower in the middle dose group and low dose group in Huoxue Runchang Soft Capsule group than those in the model control group (P<0.05 or P<0.01).There had no significant difference in plasma viscosity (P>0.05). Conclusion Huoxue Run-chang Soft Capsule has the pharmacological action of activating circulation to remove blood stasis.关键词
活血润肠软胶囊/血液流变学/影响Key words
Huoxue Runchang Soft Capsule/Hemorheology/Effect分类
医药卫生引用本文复制引用
郭金甲,党晓伟,李君,张广兴,王春民,刘洋..活血润肠软胶囊对急性血瘀模型大鼠血液流变学的影响[J].中国当代医药,2015,(21):7-9,3.
