江苏大学学报（医学版）Issue(4)：322-325,330,5.DOI:10.13312/j.issn.1671-7783.y150027
宫颈癌V MRT与常规4野放疗的剂量学比较及近期疗效观察
Analyse the dosimetric difference and evaluate short-term clinical efficacy between VMRT and conventional 4-fields radiotherapy in cervical carcinoma
王承伟 1冯志俊 1徐惠 1许刚 1薛辉 1张良1
作者信息
- 1. 江苏大学附属人民医院放射治疗中心，江苏 镇江212002
- 折叠
摘要
Abstract
Objective:To analyse the dosimetry difference and evaluate recent clinical efficacy and a-cute toxicity reaction between volume of rotating intensity-modulated radiotherapy(VMRT)and conventional pelvic 4-fields radiotherapy(4F)in advanced cervical carcinoma(stage Ⅱb-Ⅳ).Methods:There were 32 patients of advanced cervical cancer patients with newly diagnosed,and we designed both VMRT and 4F radiotherapy plan after CT simulation for all of the patients,evaluated the dosimetry of target volume and the organs at risk.The patients were divided into VMRT group(n=15)and 4F radiotherapy group(n=17)by the willingness of patients,VMRT(50 Gy/28 f)or 4F(45 -50 Gy/25 -28 f)radiotherapy carried out com-bined with brachytherapy and concurrent cisplatin chemotherapy(40 mg/m2,QW),and then compare the short term effect and acute toxicity reaction.Results:Both of uniformity(HI)and conformal(CI)of target volume in the VMRT group were better than that in the 4F group(P<0.05).In the VMRT plan,V30,V40, Dmean,D50,V40 and Dmean of the small intestine,bladder and rectum,were lower than that in 4F radiotherapy (P<0.05).Complete remission rate were 86.7%(13 cases)and 82.4%(14 cases,P>0.05)in VMRT group and 4F radiotherapy group respectively.Radiation induced enteritis and cystitisand were lower than that in 4F radiotherapy group(P<0.05).Both groups showed varying degrees of bone marrow suppression, but there was no statistically significant difference(P>0.05 ).Conclusion:In dosimetric analysis,VMRT showed advantage in the protection of organs,there was no difference between two group in the short term effect,but the incidence of acute toxicity significantly reduced.Above all,VMRT will be recommended for the patients with cervical carcinoma who received external beam irradiation.关键词
宫颈癌/常规4野放疗/容积旋转调强放疗/剂量学Key words
uterine cervical carcinoma/conventional 4-field radiotherapy/volume of rotating intensity-modulated radiotherapy/dosimetry分类
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王承伟,冯志俊,徐惠,许刚,薛辉,张良..宫颈癌V MRT与常规4野放疗的剂量学比较及近期疗效观察[J].江苏大学学报（医学版）,2015,(4):322-325,330,5.
