江苏大学学报（医学版）Issue(4)：326-330,5.DOI:10.13312/j.issn.1671-7783.y150107
高血压前期左室舒张功能改变与动脉硬化的相关性
Correlation between arterial stiffness and left ventricular diastolic function in prehypertension
摘要
Abstract
Objective:To study the correlation between left ventricular diastolic function and aortic stiff-ness in prehypertension.Methods:A total of 40 cases of untreated prehypertension as observation group and 40 pure normaltensive cases as control group.Left ventricular diastolic function was assessed by echo-cardiography,aortic distensibility parameters were derived from aortic diameters measured by ultrasonogra-phy,and vascular inflammation was assessed by high-sensitivity C-reactive protein.Results:Prehyperten-sive subjects displayed a significantly lower E/A ratio and a significantly greater deceleration time and isovo-lumetric relaxation time compared with normoltensive controls.They also displayed aortic systolic diameter, diastolic diameter and mean aortic stiffness significantly increased while systo-diastolic diameter change, mean aortic distensibility and aortic strain were significantly reduced compared with controls.Values of in-fammatory markers were increased.At multiple regression analysis,E/A ratio was significantly related to high-sensitivity C-reactive protein(β=0.002,P=0.019)and aortic stiffness(β=-0.128,P=0.028)af-ter correction for age,left ventricular mass index and mean blood pressure.Conclusion:In prehyperten-sion,the failing of left ventricular diastolic function and aortic stiffness have been started,showed significant correlation.关键词
高血压前期/动脉硬化/左室舒张功能/高敏C反应蛋白Key words
prehypertension/arterial stiffness/diastolic function/high-sensitivity C-reactive protein分类
医药卫生引用本文复制引用
葛青,袁伟,周建英,王中群,严金川..高血压前期左室舒张功能改变与动脉硬化的相关性[J].江苏大学学报（医学版）,2015,(4):326-330,5.基金项目
国家自然科学基金资助项目（81200222）；江苏省卫生厅重点项目（H201435）；镇江市心血管病学重点实验室基金资助项目 （）
