检验医学与临床Issue(z2)：187-190,4.DOI:10.3969/j.issn.1672-9455.2014.26.103
异常凝血酶原（DCP）对早期原发性肝癌的诊断价值
The early diagnostic value of des-carboxy prothrombin in primary hepatocellular carcinoma
赵婷婷1
作者信息
- 1. 湖北省荆门市第一人民医院检验科 448000
- 折叠
摘要
Abstract
Objective Explore diagnostic value of des‐carboxy prothrombin in primary hepatocellular carcino‐ma .Methods Alpha fetoprotein(AFP)and des‐carboxy prothrombin(DCP)levels in serum were detected by enzyme‐linked immunosorbent assay(ELLSA)and electro‐chemiluminescence .Among these samples 48 were with PHC ,35 were cirrhosis and 35 were healthy control group .The differences between the levels were compared and the value of DCP in diagnosis of PHC was assessed by ROC analysis .Results The value of DCP were(598 .3 ± 476 .2)ng/mL、(19 .2 ± 9 .8)ng/mL and(4 .8 ± 2 .5)ng/mL in the group of PHC ,cirrhosis and control group respectively ,and the AFP value were(710 .5 ± 409 .8)mAU/mL ,(34 .9 ± 8 .9)mAU/mL and(7 .9 ± 3 .1)ng/mL respectively .Both AFP and DCP levels in the group of PHC were higher than the other two group ,the difference between the two groups have statistical significance(P< 0 .05) .The sensitivity of DCP and AFP was 72 .1% and 91 .4% respectively ,the difference has no statistical significance(P>0 .05) ,while the specificity of DCP and AFP was 62 .2% and 71 .4% re‐spectively ,the difference has statistical significance(χ2 =4 .629 ,P<0 .05) .ROC curves indicated a better accuracy for DCP(AUC=0 .896)than AFP(AUC=0 .752)in diagnosis of PHC .Conclusion DCP is one of the good serologic in‐dicator in diagnose PHC and it could use in the clinical diagnosis .关键词
异常凝血酶原/原发性肝癌/早期诊断Key words
des-carboxy prothrombin/primary hepatocellular carcinoma/early diagnose引用本文复制引用
赵婷婷..异常凝血酶原（DCP）对早期原发性肝癌的诊断价值[J].检验医学与临床,2014,(z2):187-190,4.
