检验医学与临床Issue(15)：2148-2150,3.DOI:10.3969/j.issn.1672-9455.2015.15.004
妊娠期高血压患者血浆中NO、ET-1及MCP-1水平变化及临床意义分析
Changes and clinical significances of plasma NO,ET-1 and MCP-1 levels in patients with hypertensive disorder complica-ting pregnancy
摘要
Abstract
Objective To explore the changes and clinical significances of plasma nitric oxide(NO) ,endothelin‐1(ET‐1) and monocyte chemoattractant protein‐1(MCP‐1) levels in the patients with hypertensive disorder complica‐ting pregnancy(HDCP) .Methods 90 patients with HDCP were selected and divided into the severe preeclampsia group ,mild preeclampsia group and HDCP group according to the disease condition and contemporaneous 30 normal pregnancy women were chosen as the control group .The levels of plasma NO ,ET‐1 and MCP‐1 were tested and con‐duct the comparative analysis .Results The systolic blood pressure(SBP) and diastolic blood pressure(DBP) of the HDCP group ,mild preeclampsia group and severe preeclampsia group were significantly higher than those of the con‐trol group ,the differences were statistically significant(P< 0 .05) ;the NO level of the HDCP group ,mild preeclamp‐sia group and severe preeclampsia group were significantly lower than that of the control group ,while the levels of ET‐1 and MCP‐1 were decreased ,the differences were statistically significant(P< 0 .05) ;the levels of NO ,ET‐1 and MCP‐1 had statistically significant difference among 3 groups(P< 0 .05) ;the levels of plasma NO ,ET‐1 and MCP‐1 in the patients with HDCP showed the obvious correlation .Conclusion The imbalance of plasma NO ,ET‐1 and MCP‐1 plays an important role in the occurrence of HDCP .关键词
妊娠期高血压疾病/一氧化氮/内皮素-1/单核细胞趋化蛋白-1Key words
hypertensive disorder complicating pregnancy/nitric oxide/endothelin-1/monocyte che-moattractant protein-1引用本文复制引用
陈巍,周冰,程虹..妊娠期高血压患者血浆中NO、ET-1及MCP-1水平变化及临床意义分析[J].检验医学与临床,2015,(15):2148-2150,3.基金项目
海南省自然科学基金资助项目（812178）。 （）
