检验医学与临床Issue(15)：2175-2177,3.DOI:10.3969/j.issn.1672-9455.2015.15.014
妊娠期妇女高危型人乳头瘤病毒感染与宫颈病变的相关性研究
Correlation between cervical high-risk HPV infection with cervical lesions in pregnant women
摘要
Abstract
Objective To study the correlation between high risk human papilloma virus(HR‐HPV) infection with cervical lesions in pregnant women .Methods A total of 486 pregnant women aged 18 - 43 years old treated in our hospital were selected and performed the second generation hybrid capture technique (HC2‐HPV‐DNA ) ,and pathogens visual detection system (T H) and cervical biopsy under colposcopy .The pathology results served as the gold standard for the diagnosis of cervical lesions .Results Among 486 pregnant women ,161 cases were positive in the HR‐HPV detection with the detection rate of 33 .12% (161/486) ;24 cases of cervical cancer(ICC) and cervical intraepithelial neoplasia(CIN) were diagnosed by histopathology ,in which 22 cases were HPV positive ,the sensitivity was 91 .67% (22/24) .The HR‐HPV infection distribution had statistical difference among different age groups(P<0 .05) ,the higher the HR‐rHPV viral load ,the worse the cervical lesions .Conclusion The HR‐HPV infection rate is different in different ages of pregnant women ;HR‐HPV positive viral load is related with the occurrence of CIN and ICC ,occurrence process of cervical lesions ,but has no relation with the severity of cervical lesions ;the positive rate of cervical lesions and viral load in pregnant women HPV infection are similar to non pregnant women ;The HC2‐HPV‐DNA method is the best method for screening precancerous lesion and cervical cancer .关键词
第二代分子杂交捕获技术/超微病原体可视检测技术/病理活检/宫颈病变/高危型人乳头瘤病毒Key words
HC2-HPV-DNA/T H/pathological biopsy/cervical diseases/high risk human papilloma virus引用本文复制引用
谢建渝,虞柯静,董国强,蔡春玲,刘莉,黎义,邹光美..妊娠期妇女高危型人乳头瘤病毒感染与宫颈病变的相关性研究[J].检验医学与临床,2015,(15):2175-2177,3.基金项目
重庆市九龙坡区科委社会发展类基金资助项目（201307）。 （）
