昆明医科大学学报2015，Vol.36Issue(9)：95-97,3.
慢性阻塞性肺疾病患者血清IL-17、IL-6、IL-8、CRP、TNF-α的变化及其相关性
The Changes and Correlation of Serum IL-17, IL-6, IL-8,CRP and TNF-α of Patients with Chronic Obstructive Pulmonary Diseases
摘要
Abstract
Objective To study the changes and correlation of serum interleukin-17,-6 and-8 (IL-17,IL-6 and IL-8),c-reactive protein (CRP),tumor necrosis factor alpha (TNF-α) of patients with chronic obstructive pulmonary diseases (COPD),and discuss the role and clinical significance of these factors in the occurrence and development of COPD.Methods 100 COPD patients were selected (COPD group),and 50 healthy elderly people in the same period in outpatient medical examination were served as control (control group).The levels ofIL-17,IL-6 and IL-8,CRP,TNF-α in serum were detected with ELISA method.Results The serum levels of IL-17,IL-6,IL-8,CRP and TNF-α of patients in COPD group were higher than those in the control group (P ＜ 0.01),and of patients with acute aggravating period were higher than those of patients with stable period (P ＜ 0.05 or P ＜ 0.01).Pearson correlation analysis showed there were positive correlations among IL-17,IL-6,IL-8,CRP and TNF-α (P ＜ 0.05) Conclusion The serum levels of IL-17,IL-6,IL-8,CRP and TNF-α of COPD patients have abnormal increased,and will increase with the rise of the illness severity.The above factors may be involved in the airway in patients with acute inflammatory reaction and the development process.关键词
慢性阻塞性肺疾病/白细胞介素17/白细胞介素6/白细胞介素8/C反应蛋白/肿瘤坏死因子αKey words
Chronic obstructive pulmonary diseases/IL-17/IL-6/IL-8/CRP/TNF-α分类
医药卫生引用本文复制引用
杜海莲,岳红梅..慢性阻塞性肺疾病患者血清IL-17、IL-6、IL-8、CRP、TNF-α的变化及其相关性[J].昆明医科大学学报,2015,36(9):95-97,3.基金项目
甘肃省科技计划立项项目(1105TCYA0I2) （1105TCYA0I2）
