中国临床保健杂志Issue(4)：340-342,3.DOI:10.3969/J.issn.1672-6790.2015.04.002
N末端脑钠肽前体、超敏C反应蛋白、同型半胱氨酸在老年慢性心力衰竭患者中的临床意义
Clinical significance of N-terminal pro-brain natriuretic peptide,high-sensitivity C-reactive protein,and ho-mocysteine in elderly patients with chronic heart failure
摘要
Abstract
Objective To explore the clinical significance of N-terminal pro-brain natriuretic peptide (NT-proBNP),high-sensitivity C-reactive protein (hs-CRP),and homocysteine (HCY)in elderly patients with chronic heart failure (CHF),and their relationships with left ventricular ejection fraction (LVEF).Methods Ninety-two elderly patients with CHF were collected as observation group,while 52 healthy elderly people were selected as con-trols.The NT-proBNP,hs-CRP,and HCY of serum were detected.The LVEF was measured by ultrasonic cardiogram, and the correlation between NT-proBNP,hs-CRP,HCY and LVEF was analyzed.Results The serum NT-proBNP,hs-CRP,and HCY in observation group were significantly higher than those in the control group respectively,while the LVEF in the observation group was significantly lower than that in the control group ,and the difference was statistical-ly significant (P <0.01).The levels of serum NT-proBNP,hs-CRP,and HCY gradually increased,while the LVEF decreased as the NYHA classification increased,and the difference among different grade were statistically significant (P <0.05).The analysis showed that there were negative correlations between NT-proBNP,hs-CRP,HCY and the LVEF(r =-0.65,-0.24,-0.45,P <0.05),especialy the correlation between NT-proBNP and LVEF was the most obvious one.Conclusion The serum NT-proBNP,HCY,and hs-CRP increase with the degree of heart failure.关键词
心力衰竭/促尿钠排泄肽类/C反应蛋白质/半胱氨酸/每搏输出量/老年人Key words
Heart failure/Natriuretic peptides/C-reactive protein/Cysteine/Stroke volume/Aged分类
医药卫生引用本文复制引用
买买提吐尔洪·吐尔逊,袁红,徐红,冯媛媛..N末端脑钠肽前体、超敏C反应蛋白、同型半胱氨酸在老年慢性心力衰竭患者中的临床意义[J].中国临床保健杂志,2015,(4):340-342,3.基金项目
新疆维吾尔自治区人民医院科研项目 （）
