中国临床保健杂志Issue(4)：364-366,3.DOI:10.3969/J.issn.1672-6790.2015.04.011
慢性肾脏病患者颈动脉病变的特点及其危险因素
Serum vitamin D concentration and carotid atherosclerosis in chronic kidney disease
摘要
Abstract
Objective To understand clinical feature of carotid artery disease,and to investigate the relation-ship between 25-hydroxy vitamin D and carotid atherosclerosis in chronic kidney disease (CKD)patients.Methods 80 CKD (2-5ND ) patients were enrolled into this cross-sectional observational study.Serum 25-OH-D3 , 1,25(OH)2 D3 ,the other related clinical biochemical examinations and carotid artery intimal medial thickness (IMT) were measured.According to the result of carotid artery color Doppler ultrasound,the patients were divided into two groups:carotid artery thickening group and carotid artery non-thickening group;further the patients with carotid arter-y thickening were divided into carotid artery plaque group and non-carotid artery plaque group.The possible risk fac-tors for carotid atherosclerosis were analyzed and compared between the two groups.Results In 80 CKD patients,the incidence of carotid artery thickening、carotid artery plaque and arteriostenosis was 63.7% (51 /80 ),45.0%(36 /80),12.5% (36 /80),respectively;in the patients with carotid artery thickening,the incidence of carotid arter-y plaque was 70.6% (36 /51).Age、hypertension、e-GFR、HGB、HCT、CRP、cardiac valves calcification、primary glo-merular disease had statistical difference between carotid artery thickening group and non-thickening group(P <0.01 or 0.05).Multivariate logistic gradual regressive analysis showed that hypertension can enter the regression equation (β=1.67,OR =5.29,P =0.004).Age and RBC count were significantly difference in patients with carotid plaque compared patients without carotid plaque(P <0.05).Conclusion Hypertension is independent risk factor of carotid artery thickening,Age and lowering RBC count probably have an effect on the occurrence of carotid artery thickening and plaque in CKD patients.关键词
肾疾病/颈动脉内膜中膜厚度/血栓栓塞/高血压Key words
Kidney diseases/Carotid intima-media thickness/Thromboembolism/Hypertension分类
医药卫生引用本文复制引用
李湛,杨继红,张燕京,孙颖,王川予..慢性肾脏病患者颈动脉病变的特点及其危险因素[J].中国临床保健杂志,2015,(4):364-366,3.基金项目
北京医院院内青年课题（BJ-2012-72）；2013年度人力资源和社会保障部留学人员科技活动项目择优基金资助 （）
