中国临床保健杂志Issue(4)：380-382,3.DOI:10.3969/J.issn.1672-6790.2015.04.016
心肌梗死患者急诊经皮冠状动脉介入术应用替罗非班的临床观察
The Clinical observation of application of tirofiban on patients with acute myocardial infarction during emer-gency PCI
韩增雷 1张玉英 2曹庆博1
作者信息
- 1. 山东青岛市第八人民医院心内科，266100
- 2. 青岛市城阳区流亭医院
- 折叠
摘要
Abstract
Objective To explore the effects and the clinical signifcance of early application of tirofiban in patients with acute myocardial infarction (STEMI)before primary pereutaneous coronary intervention (PCI).Method A total of 112 STEMI patients were divided into tirofiban group(n =56)and control group(n =56)according to whether intracoronary using tirofiban.TIMI grade,corrected TIMI frame count(CTFC),hs-CRP and LVEF after PCI operation and the incidence of major adverse cardiac events and bleeding case were compared between two groups.Re-sults The percentage of TIMI 3 flow achieved in tirofiban group after PCI was higher than that in control (93.8%∶79.2%,P <0.01).The TIMI frame count showed coronary blood flow in the tirofiban group was significant-ly faster than the control group (23.1 ±5.9)frame∶(32.4 ±4.8)frame,P <0.01.The postoperative hs-CRP of tiro-fiban group was significantly lower than that in the control group (7.2 ±0.8)∶(9.6 ±1.1),P <0.01;the LVEF val-ues of one week after operation in experimental group was significantly higher (68.7% ±8.5%)∶(55% ±9.2%), P <0.01.Conclusion The tirofiban can significantly improve coronary blood flow,myocardial perfusion and cardiac function in STEMI patients with emergency PCI therapeutic,and don′t significantly increase the incidence of major bleeding events,which may improve short-term prognosis.关键词
血管成形术/心肌梗死/血小板膜糖蛋白类Key words
Angioplasty/Myocardial infarction/Platelet membrane glycoproteins分类
医药卫生引用本文复制引用
韩增雷,张玉英,曹庆博..心肌梗死患者急诊经皮冠状动脉介入术应用替罗非班的临床观察[J].中国临床保健杂志,2015,(4):380-382,3.
