药学研究Issue(8)：451-452,471,3.
HPLC 法测定依托度酸胶囊的含量
Determination of etodolac in Etodolac Capsules by HPLC
王增日1
作者信息
- 1. 鲁南制药集团股份有限公司，山东 临沂 276000
- 折叠
摘要
Abstract
Objective To establish an HPLC method for the determination of etodolac in Etodolac Capsules. Methods HPLC method was adopted with Diamonsil C18 column(4. 6 mm × 150 mm,5 μm). A mixture of acetonitrile:water +phosphoric acid[520:480(500 + 0. 25)]was used as the mobile phase. The flow rate was 1. 5 mL·min - 1 with the detec-tion wavelength at 274 nm. Results At the validated method,the excipient had no interference to the principal agent. A lin-ear range of etodolac was 24. 98 ~ 199. 8 μg·mL - 1(r = 0. 999 9). The average recovery was 99. 6% with RSD = 0. 47%(n = 9). Conclusion This method was simple,accurate,specific and could be used for the determination of etodolac in Etodolac Capsules.关键词
依托度酸/高效液相色谱法/含量测定/胶囊Key words
Etodolac/HPLC/Determination/Capsule分类
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王增日..HPLC 法测定依托度酸胶囊的含量[J].药学研究,2015,(8):451-452,471,3.
